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Cat#：203P17
序列（三字母）：H-Glu-Leu-Asp-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]-Val-Glu-Phe-Gly-Gly-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-OH trifluoroacetate salt
序列（單字母）：ELD[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]VEFGGrrrrrrrrr
類似名：[OM00-3]r?, [OM00-3]DR?
分子式：C???H???N??O??
分子量：2455.86
CAS#：527674-72-2
合成方法：Synthetic
存儲條件：-20 ± 5 °C
應(yīng)用：Alzheimer´s Disease
描述：A memapsin-2 (β-secretase) inhibitor consisting of the transition-state inhibitor of memapsin-2, OM00-3, (Ki = 0.31 nM) covalently linked to a nine-residue poly D-arginine carrier protein. [OM00-3]r? (ELDLpsi[CHOH-CH?]AVEFGGr?) was shown to penetrate the plasma membrane of cultured cells and to inhibit production of amyloid β-protein. In transgenic Tg2576 mice with amyloid plaque pathology intraperitoneal injection of N-1920 resulted in a significant decrease in amyloid β-protein levels in plasma and brain.