產(chǎn)品詳情
Cat#: 112P68
序列（三字母）：Cyclo(-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg)(Disulfide bonds between Cys3 and Cys1?/Cys? and Cys1?/Cys? and Cys12)
序列（單字母）：Cyclo(-GICRCICGRGICRCICGR)
類似名：RC-100
分子式：C??H???N??O??S?
分子量：1918.42
CAS#：724760-19-4
合成方法：固相合成
存儲(chǔ)條件：-20 ± 5 °C，避光，干燥
應(yīng)用：Antimicrobial & Antiviral Peptides|
Infectious Disease
描述：The theta-defensin retrocyclin-1, also called RC-100, is a circular octadecapeptide containing an internal trisulfide ladder. Besides its antimicrobial activity, retrocyclin-1 has a remarkable ability to protect human cells in vitro from infection by T- and M-tropic strains of HIV-1. Its effectiveness against HIV-1 results from the prevention of viral entry, and is correlated with its ability to recognize and bind with high affinity to glycoproteins and glycolipids implicated in HIV-1 entry, such as gp120 (KD = 35.4 nM), CD4 (KD = 31 nM), and galactosylceramide (KD = 24.1 nM). Retrocyclin represents a new class of small molecule HIV-1 entry inhibitors.
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