產(chǎn)品詳情
Cat#: 114P06
序列（三字母）：H-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
序列（單字母）：KFRRQRPRLSHKGPMPF
類似名：Preproapelin (61-77) (human, bovine, mouse, rat), Apelin Precursor (61-77) (human, bovine, mouse, rat)
分子式：C??H???N??O??S
分子量：2138.58
CAS#：217082-57-0
合成方法：固相合成
存儲(chǔ)條件：-20 ± 5 °C，避光，干燥
應(yīng)用：Virology
描述：Apelin-17 is an endogenous ligand of the human orphan G protein-coupled receptor APJ, reported to act as a coreceptor of CD4 for human and simian immunodeficiency viruses. Apelin-17 and apelin-13 represent the predominant molecular forms of apelin present in the whole brain, hypothalamus, and plasma. Like apelin-13, apelin-17 exhibited a high activity on extracellular acidification rate and strongly inhibited forskolin-stimulated cAMP production in CHO cells expressing the human or the rat apelin receptor. The peptide might play a crucial role in the maintenance of body fluid homeostasis by counteracting AVP (arginine vasopressin) actions through inhibition of AVP neuron activity and AVP release.
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